The STARDdem Initiative - enhanced reporting guidance for diagnostic studies


The Cochrane Dementia and Cognitive Improvement Group (CDCIG) set up and co-ordinated an initiative to review the current standard of reporting in diagnostic test accuracy studies in dementia and cognitive impairment, and to generate, through a consensus process, enhanced guidance to the STARD checklist: the STARDdem Initiative.

The STARD Statement was published in 2003 by Patrick Bossuyt and colleagues and can be accessed at

The STARDdem initiative comprised three broad phases:

Phase 1: Evaluation of existing studies through a systematic literature review. This has now been published:

Noel-Storr AH, Flicker L, Ritchie CW, Nguyen GH, Gupta T, Wood P, Walton J, Desai M, Fraser Solomon D, Molena E, Worrall R, Hayen A, Choudhary P, Ladds E, Lanctot KL, Verhey FR, McCleery JM, Mead G, Clare L, Fiorivanti M, Hyde C, Marcus S, McShane R. Systematic review of the body of evidence for use of biomarkers in the diagnosis of dementia. Alzheimer’s & Dementia 2013; 9: e96-e105

The review of dementia studies published in 2013 found that many studies failed to report on key areas.

Phase 2: Formation of a Working Group who drafted initial supplementary guidance using a modified Delphi technique. The draft guidance was sent to over 350 experts. Feedback was collated and incorporated and presented at a consensus meeting.

The following documents can be accessed and downloaded below:

First draft of supplementary guidance

Comments received during wider participation round

Phase 3: Publication and further dissemination of the supplementary guidance - Just published!

Anna H. Noel-Storr, Jenny M. McCleery, Edo Richard, Craig W. Ritchie, Leon Flicker, Sarah J. Cullum, Daniel Davis, Terence J. Quinn, Chris Hyde, Anne W.S. Rutjes, Nadja Smailagic, Sue Marcus, Sandra Black, Kaj Blennow, Carol Brayne, Mario Fiorivanti, Julene K. Johnson, Sascha Köpke, Lon S. Schneider, Andrew Simmons, Niklas Mattsson, Henrik Zetterberg,  Patrick M.M. Bossuyt, Gordon Wilcock, Rupert McShane. Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative. Neurology 2014

If you have any questions or want to find out a bit more about this initiative please do get in touch: